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In season six's "The 43 Peculiarity", she tells him she loves him for the first time, and this now makes them more comfortable in their relationship.
Sheldon has a superiority complex and makes no effort to hide his contempt for other people's lower intellects, often making highly inappropriate comments.
His father, George, whose death antedates the series, is described as a stereotypical Texan who liked football, skeet shooting, and heavy drinking; his mother, Mary, is a devout Evangelical Christian, who does not seem to understand her son's fields of study, although she does display common sense and intelligence; his fraternal twin sister, Missy, and as-yet unseen brother, George Jr., were both described by Mary as being "dumb as soup".
His sister later has a baby boy, making Sheldon an uncle.
Aside from Penny, Leonard has had romantic relationships with co-worker Leslie Winkle, physician Stephanie Barnett, an unnamed French literature Ph D, and North Korean spy Joyce Kim.
Following his break-up with Penny, Leonard began a relationship with Raj's sister Priya in season four, and it is implied they had a brief sexual encounter before the start of the series.